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  1. Content type: Research

    Despite efforts to increase diversity in clinical trials, racial/ethnic minority groups generally remain underrepresented, limiting researchers’ ability to test the efficacy and safety of new interventions acr...

    Authors: Rossybelle P. Amorrortu, Mariana Arevalo, Sally W. Vernon, Arch G. Mainous III, Vanessa Diaz, M. Diane McKee, Marvella E. Ford and Barbara C. Tilley

    Citation: Trials 2018 19:115

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  2. Content type: Study protocol

    During the last decade, the use of ministernotomy in cardiac surgery has increased. Quality of life and patient satisfaction after ministernotomy have never been compared to conventional full sternotomy in ran...

    Authors: Emiliano A. Rodríguez-Caulo, Ana Guijarro-Contreras, Juan Otero-Forero, María José Mataró, Gemma Sánchez-Espín, Arantza Guzón, Carlos Porras, Miguel Such, Antonio Ordóñez, José María Melero-Tejedor and Manuel Jiménez-Navarro

    Citation: Trials 2018 19:114

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  3. Content type: Research

    Shorter-duration antibiotic treatment is sufficient for a range of bacterial infections, but has not been adequately studied for bloodstream infections. Our systematic review, survey, and observational study i...

    Authors: Nick Daneman, Asgar H. Rishu, Ruxandra Pinto, Pierre Aslanian, Sean M. Bagshaw, Alex Carignan, Emmanuel Charbonney, Bryan Coburn, Deborah J. Cook, Michael E. Detsky, Peter Dodek, Richard Hall, Anand Kumar, Francois Lamontagne, Francois Lauzier, John C. Marshall…

    Citation: Trials 2018 19:111

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  4. Content type: Study protocol

    There is a need for evidence of the effectiveness of pre-operative exercise for patients undergoing major cancer surgery; however, recruitment to such trials can be challenging. The PrE-operative Physical Acti...

    Authors: Daniel Steffens, Jane Young, Paula R. Beckenkamp, James Ratcliffe, Freya Rubie, Nabila Ansari, Neil Pillinger and Michael Solomon

    Citation: Trials 2018 19:112

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  5. Content type: Research

    There are numerous challenges in including patients in a core outcome set (COS) study, these can vary depending on the patient group. This study describes current efforts to include patients in the development...

    Authors: Alice M. Biggane, Lucy Brading, Philippe Ravaud, Bridget Young and Paula R. Williamson

    Citation: Trials 2018 19:113

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  6. Content type: Study protocol

    Help-seeking for alcohol use disorders (AUDs) is low and traditional treatments are often perceived as stigmatizing. Physical activity has positive effects on mental and physical health which could benefit thi...

    Authors: Mats Hallgren, Victoria Andersson, Örjan Ekblom and Sven Andréasson

    Citation: Trials 2018 19:106

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  7. Content type: Study protocol

    Transcervical resection of myoma or endometrium is a safe, hysteroscopic, minimally invasive procedure. However, intravasation of distension fluid is a common phenomenon during these procedures. In a previous ...

    Authors: Lucilla E. Overdijk, Bart M. P. Rademaker, Paul J. M. van Kesteren, Peter de Haan, Robert K. Riezebos and Oscar C. H. Haude

    Citation: Trials 2018 19:107

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  8. Content type: Study protocol

    The optimal approach to the drainage of malignant obstruction at the liver hilum remains uncertain. We aim to compare percutaneous transhepatic biliary drainage (PTBD) to endoscopic retrograde cholangiography ...

    Authors: Firas Al-Kawas, Harry Aslanian, John Baillie, Filip Banovac, Jonathan M. Buscaglia, James Buxbaum, Amitabh Chak, Bradford Chong, Gregory A. Coté, Peter V. Draganov, Kulwinder Dua, Valerie Durkalski, B. Joseph Elmunzer, Lydia D. Foster, Timothy B. Gardner, Brian S. Geller…

    Citation: Trials 2018 19:108

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  9. Content type: Study protocol

    The frequency of posterior presentations (occiput of the fetus towards the sacrum of the mother) in labor is approximately 20% and, of this, 5% remain posterior until the end of labor. These posterior presenta...

    Authors: C. Verhaeghe, E. Parot-Schinkel, P. E. Bouet, S. Madzou, F. Biquard, P. Gillard, P. Descamps and G. Legendre

    Citation: Trials 2018 19:109

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  10. Content type: Study protocol

    Although surgical resection has been considered the only curative option for colorectal liver metastases (CLM), thermal ablation has recently been suggested as an alternative curative treatment. A prospective ...

    Authors: Kurinchi Gurusamy, Neil Corrigan, Julie Croft, Maureen Twiddy, Stephen Morris, Nick Woodward, Steve Bandula, Daniel Hochhauser, Vicky Napp, Alison Pullan, Nicholas Jakowiw, Raj Prasad, Steven Olde Damink, C. J. H. M. van Laarhoven, Johannes H. W. de Wilt, Julia Brown…

    Citation: Trials 2018 19:105

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  11. Content type: Study protocol

    Carvedilol is a non-selective, third-generation beta-blocker and is one of the cornerstones for treatment for patients with heart failure and reduced ejection fraction (HFrEF). However, due to its short half-l...

    Authors: Dong-Ju Choi, Chan Soon Park, Jin Joo Park, Hae-Young Lee, Seok-Min Kang, Byung-Su Yoo, Eun-Seok Jeon, Seok Keun Hong, Joon-Han Shin, Myung-A Kim, Dae-Gyun Park, Eung-Ju Kim, Soon-Jun Hong, Seok Yeon Kim and Jae-Joong Kim

    Citation: Trials 2018 19:103

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  12. Content type: Correction

    In the original publication [1] the figure captions of Figs. 2 and 3 were reversed. The correct version can be found in this Erratum.

    Authors: Nadia A. Sam-Agudu, Jennifer R. Pharr, Tamara Bruno, Chad L. Cross, Llewellyn J. Cornelius, Prosper Okonkwo, Bolanle Oyeledun, Hadiza Khamofu, Ayodotun Olutola, Salome Erekaha, William Nii Ayitey Menson and Echezona E. Ezeanolue

    Citation: Trials 2018 19:104

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    The original article was published in Trials 2017 18:595

  13. Content type: Study protocol

    Cognitive rehabilitation is a highly individualised, non-pharmacological intervention for people with mild cognitive impairment (MCI) and dementia, which in recent years has also been developed for various IT ...

    Authors: Martina Vanova, Eider Irazoki, J. Antonio García-Casal, Fernando Martínez-Abad, Cristina Botella, Kate R. Shiells and Manuel A. Franco-Martín

    Citation: Trials 2018 19:100

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  14. Content type: Study protocol

    Resistant hypertension is characterized when the blood pressure (BP) remains above the recommended goal after taking three antihypertensive drugs with synergistic actions at their maximum recommended tolerated...

    Authors: Elizabeth do Espirito Santo Cestário, Letícia Aparecida Barufi Fernandes, Luiz Tadeu Giollo-Júnior, Jéssica Rodrigues Roma Uyemura, Camila Suemi Sato Matarucco, Manoel Idelfonso Paz Landim, Luciana Neves Cosenso-Martin, Lúcia Helena Bonalume Tácito, Heitor Moreno Jr., José Fernando Vilela-Martin and Juan Carlos Yugar-Toledo

    Citation: Trials 2018 19:101

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  15. Content type: Study protocol

    Globally, the rapid development of mobile technology has created new ways of addressing public health challenges and shifted the paradigm of health care access and delivery. The primary aim of this study is to...

    Authors: Tilayie Feto Gelano, Nega Assefa, Yadeta Dessie Bacha, Afendi Abdi Mahamed, Kedir Teji Roba and Mitiku Teshome Hambisa

    Citation: Trials 2018 19:102

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  16. Content type: Study protocol

    Family caregivers of aged stroke survivors face challenging difficulties such as the lack of support and the knowledge and skills to practice home care. These aspects negatively influence the caregivers’ burde...

    Authors: Carolina Baltar Day, Carla Cristiane Becker Kottwitz Bierhals, Naiana Oliveira dos Santos, Duane Mocellin, Mariane Lurdes Predebon, Fernanda Laís Fengler Dal Pizzol and Lisiane Manganelli Girardi Paskulin

    Citation: Trials 2018 19:96

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  17. Content type: Study protocol

    Hwa-byung (HB) is an anger syndrome caused by an inadequate release of accumulated anger that leads to somatic and psychiatric symptoms. As HB results from long-term inadequately treated negative emotions, its sy...

    Authors: Hye-Yoon Lee, Jung-Eun Kim, Mikyung Kim, Ae-Ran Kim, Hyo-Ju Park, O-Jin Kwon, Jung-Hyo Cho, Sun-Yong Chung and Joo-Hee Kim

    Citation: Trials 2018 19:98

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  18. Content type: Study protocol

    Hypertension markedly increases the risk of cardiovascular diseases and overall mortality. Lifestyle modifications, such as increased levels of physical activity, are recommended as the first line of anti-hype...

    Authors: Martin Grønbech Jørgensen, Jesper Ryg, Mathias Brix Danielsen, Pascal Madeleine and Stig Andersen

    Citation: Trials 2018 19:97

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  19. Content type: Correction

    After publication of this supplement [1], it was brought to our attention that two authors were missing for abstract P66: Recruitment aids for a phase II randomised trial in low risk bladder cancer. The two missi...

    Authors: Steven Penegar, Rebecca Lewis, James Catto, Joanne Cresswell, Leyshon Griffiths, Micki Hill, John Kelly, Allen Knight, John McGrath, Laura Wiley, Hugh Mostafid and Emma Hall

    Citation: Trials 2018 19:99

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    The original article was published in Trials 2017 18:200

  20. Content type: Research

    Patient and public involvement (PPI) in clinical trials aims to ensure that research is carried out collaboratively with patients and/or members of the public. However, current guidance on involving clinical t...

    Authors: Claire L. Vale, William J. Cragg, Ben Cromarty, Bec Hanley, Annabelle South, Richard Stephens, Kate Sturgeon and Mitzy Gafos

    Citation: Trials 2018 19:95

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  21. Content type: Study protocol

    Patients admitted to intensive care units (ICU) with acute respiratory failure (ARF) face chronic complications that can impede return to normal daily function. A mobile, collaborative critical care model may ...

    Authors: Sikandar Khan, Ashok Biju, Sophia Wang, Sujuan Gao, Omar Irfan, Amanda Harrawood, Stephanie Martinez, Emily Brewer, Anthony Perkins, Frederick W. Unverzagt, Sue Lasiter, Ben Zarzaur, Omar Rahman, Malaz Boustani and Babar Khan

    Citation: Trials 2018 19:94

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  22. Content type: Study protocol

    One-year dual antiplatelet therapy (DAPT), generally aspirin in combination with a P2Y12 receptor inhibitor, has been a standard treatment for patients undergoing percutaneous coronary intervention (PCI). Prol...

    Authors: Jingen Li, Jianqing Ju, Zhuo Chen, Jing Liu, Fang Lu, Rui Gao and Hao Xu

    Citation: Trials 2018 19:93

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  23. Content type: Research

    Methodological research into the design, conduct, analysis and reporting of trials is essential to optimise the process. UK specialists in the field have established a set of top priorities in aid of this rese...

    Authors: Anna Rosala-Hallas, Aneel Bhangu, Jane Blazeby, Louise Bowman, Mike Clarke, Trudie Lang, Mona Nasser, Nandi Siegfried, Karla Soares-Weiser, Matt R. Sydes, Duolao Wang, Junhua Zhang and Paula R. Williamson

    Citation: Trials 2018 19:48

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